Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients.

Schleibinger, Michael; Steinbach, Cathérine L; Töpper, Christoph; Kratzer, Alexander; Liebchen, Uwe; Kees, Frieder; Salzberger, Bernd; Kees, Martin G

Schleibinger, Michael; Steinbach, Cathérine L; Töpper, Christoph; Kratzer, Alexander; Liebchen, Uwe; Kees, Frieder; Salzberger, Bernd; Kees, Martin G.

Afiliação

Schleibinger M; Department of Internal Medicine I, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.
Steinbach CL; Department of Anaesthesiology and Intensive Care, Charité Universitätsmedizin Berlin - Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany.
Töpper C; Department of Anaesthesiology and Intensive Care, Charité Universitätsmedizin Berlin - Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany.
Kratzer A; Hospital Pharmacy, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.
Liebchen U; Department of Pharmaceutical Biology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
Kees F; Department of Internal Medicine I, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.
Salzberger B; Department of Pharmacology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany.
Kees MG; Department of Internal Medicine I, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany.

Br J Clin Pharmacol ; 80(3): 525-33, 2015 Sep.

Article em En | MEDLINE | ID: mdl-25808018

Assuntos

Antibacterianos/sangue; Ceftriaxona/sangue; Albumina Sérica/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Antibacterianos/administração & dosagem; Antibacterianos/uso terapêutico; Ceftriaxona/administração & dosagem; Ceftriaxona/uso terapêutico; Simulação por Computador; Estado Terminal/terapia; Relação Dose-Resposta a Droga; Feminino; Taxa de Filtração Glomerular; Humanos; Unidades de Terapia Intensiva; Masculino; Taxa de Depuração Metabólica; Pessoa de Meia-Idade; Ligação Proteica; Fatores de Tempo

Palavras-chave

HPLC; albumin; cystatin C; dosing; pharmacodynamics; ultrafiltration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceftriaxona / Albumina Sérica / Antibacterianos Tipo de estudo: Guideline / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2015 Tipo de documento: Article

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