The change in nasal inflammatory markers after intranasal challenges with particulate chitin and lipopolysaccharide: a randomized, double-blind, placebo-controlled, crossover study with a positive control.

Sigsgaard, Torben; Thorne, Peter S; Schlünssen, Vivi; Bønløkke, Jakob; Riddervold, Ingunn S; Hoppe, Kimberly A; Andersen, Niels Trolle; Mackenzie, Neill M

Sigsgaard, Torben; Thorne, Peter S; Schlünssen, Vivi; Bønløkke, Jakob; Riddervold, Ingunn S; Hoppe, Kimberly A; Andersen, Niels Trolle; Mackenzie, Neill M.

Afiliação

Sigsgaard T; Section of Environment, Occupation and Health, Department of Public Health, University of Aarhus, Aarhus, Denmark.
Thorne PS; College of Public Health, Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA.
Schlünssen V; Section of Environment, Occupation and Health, Department of Public Health, University of Aarhus, Aarhus, Denmark.
Bønløkke J; Section of Environment, Occupation and Health, Department of Public Health, University of Aarhus, Aarhus, Denmark.
Riddervold IS; Section of Environment, Occupation and Health, Department of Public Health, University of Aarhus, Aarhus, Denmark.
Hoppe KA; College of Public Health, Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA.
Andersen NT; Section of Biostatistics, Department of Public Health, University of Aarhus, Aarhus, Denmark.
Mackenzie NM; Roji Ltd, Welwyn Garden City, Hertfordshire, UK.

Int Forum Allergy Rhinol ; 5(8): 716-23, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25851155

Assuntos

Quitina/farmacologia; Lipopolissacarídeos/farmacologia; Mucosa Nasal/metabolismo; Rinite/metabolismo; Administração Intranasal; Adulto; Biomarcadores/metabolismo; Contagem de Células; Quitina/administração & dosagem; Estudos Cross-Over; Citocinas/metabolismo; Método Duplo-Cego; Regulação para Baixo; Feminino; Voluntários Saudáveis; Humanos; Imunidade Humoral/fisiologia; Interleucina-4/metabolismo; Interleucina-6/metabolismo; Lipopolissacarídeos/administração & dosagem; Masculino; Mucosa Nasal/imunologia; Obstrução Nasal/induzido quimicamente; Prurido/induzido quimicamente; Rinite/imunologia; Método Simples-Cego; Espirro/efeitos dos fármacos; Células Th2/imunologia; Adulto Jovem

Palavras-chave

LPS; allergy; chitin; innate immunity; nasal instillation

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Quitina / Rinite / Lipopolissacarídeos / Mucosa Nasal Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Int Forum Allergy Rhinol Ano de publicação: 2015 Tipo de documento: Article

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