Prognostic Value of C-met Expression in Cholangiocarcinoma.
Technol Cancer Res Treat
; 15(2): 227-33, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-25873560
ABSTRACT
AIM:
To explore the relationship of clinicopathological features and the proteins of C-met expression in the prognosis of cholangiocarcinoma.METHODS:
Clinical data and the completed follow-up information of patients with cholangiocarcinoma who underwent cholangiocarcinoma operation from January 2004 to December 2010 were analyzed retrospectively. The relationship of clinicopathological features and C-met in the prognosis of the patients was analyzed.RESULTS:
Patients with high expression of C-met had significantly shorter overall survival than those with low expression of C-met, the difference being statistically significant (P = .003). Patients with high C-met expression had significantly shorter disease-free survival time than those with low expression of C-met, the difference being statistically significant (P = .009). By COX multivariate analysis, high C-met expression in tumor tissues was an independent risk factor in predicting overall survival and disease-free survival for patients with cholangiocarcinoma (P = .038, .048, relative risk = 1.390, 1.427).CONCLUSION:
Patients with high C-met expression in cancer tissues had shorter disease-free survival and overall survival. High expression of C-met is an independent risk factor for overall survival and disease-free survival.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
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Biomarcadores Tumorais
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Colangiocarcinoma
/
Proteínas Proto-Oncogênicas c-met
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Technol Cancer Res Treat
Ano de publicação:
2016
Tipo de documento:
Article