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Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.
Rasmussen, Kasper D; Jia, Guangshuai; Johansen, Jens V; Pedersen, Marianne T; Rapin, Nicolas; Bagger, Frederik O; Porse, Bo T; Bernard, Olivier A; Christensen, Jesper; Helin, Kristian.
Afiliação
  • Rasmussen KD; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Jia G; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Johansen JV; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark;
  • Pedersen MT; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Rapin N; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark; Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; The Finsen Laboratory, Rigshos
  • Bagger FO; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark; Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; The Finsen Laboratory, Rigshos
  • Porse BT; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark; Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; The Finsen Laboratory, Rigshos
  • Bernard OA; INSERM U985, Institut Gustave Roussy, 94805 Villejuif, France.
  • Christensen J; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Helin K; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark; Centre for Epigenetics, University of Copenhagen, 2200 Copenhagen, Denmark; The Danish Stem Cell Center (Danstem), University of Copenhagen, 2200 Copenhagen, Denmark; kristian.helin@bric.ku.dk.
Genes Dev ; 29(9): 910-22, 2015 May 01.
Article em En | MEDLINE | ID: mdl-25886910
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas / Elementos Facilitadores Genéticos / Metilação de DNA / Proteínas de Ligação a DNA / Carcinogênese Limite: Animals / Humans Idioma: En Revista: Genes Dev Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas / Elementos Facilitadores Genéticos / Metilação de DNA / Proteínas de Ligação a DNA / Carcinogênese Limite: Animals / Humans Idioma: En Revista: Genes Dev Ano de publicação: 2015 Tipo de documento: Article