[Experimental comparative pharmacokinetics of levofloxacin, triazavirin, and related conjugate].
Eksp Klin Farmakol
; 78(2): 34-8, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-25898546
ABSTRACT
A comparative study of the pharmacokinetics of levofloxacin and triazavirine as well as 2-methylthio-6-nitro-1,2,4-triazolo[5,1-ñ]-1,2,4-triazine-7(4Í)-ide (3S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7H-pyrido[1,2,3-d,e]-1,4-benzoxazine-6-carboxylic acid (conjugate 2) obtained by conjugation of triazavirine and levofloxacin, representing a new class of pharmacological agents, was carried out in experiments on rats. It is established that conjugate 2 in comparison to individual levofloxacin and triazavirine has a higher relative bioavailability and lower rate of elimination, which can lead to improved effectiveness of therapy at reduced dose and frequency of drug administration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Triazinas
/
Ácidos Carboxílicos
/
Levofloxacino
/
Anti-Infecciosos
Limite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Ano de publicação:
2015
Tipo de documento:
Article