Sequencing and beyond: integrating molecular 'omics' for microbial community profiling.
Nat Rev Microbiol
; 13(6): 360-72, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25915636
ABSTRACT
High-throughput DNA sequencing has proven invaluable for investigating diverse environmental and host-associated microbial communities. In this Review, we discuss emerging strategies for microbial community analysis that complement and expand traditional metagenomic profiling. These include novel DNA sequencing strategies for identifying strain-level microbial variation and community temporal dynamics; measuring multiple 'omic' data types that better capture community functional activity, such as transcriptomics, proteomics and metabolomics; and combining multiple forms of omic data in an integrated framework. We highlight studies in which the 'multi-omics' approach has led to improved mechanistic models of microbial community structure and function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Perfilação da Expressão Gênica
/
Proteômica
/
Biologia de Sistemas
/
Metabolômica
/
Metagenômica
/
Microbiota
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Microbiol
Ano de publicação:
2015
Tipo de documento:
Article