Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation.

Palmieri, Erika M; Spera, Iolanda; Menga, Alessio; Infantino, Vittoria; Porcelli, Vito; Iacobazzi, Vito; Pierri, Ciro L; Hooper, Douglas C; Palmieri, Ferdinando; Castegna, Alessandra

Palmieri, Erika M; Spera, Iolanda; Menga, Alessio; Infantino, Vittoria; Porcelli, Vito; Iacobazzi, Vito; Pierri, Ciro L; Hooper, Douglas C; Palmieri, Ferdinando; Castegna, Alessandra.

Afiliação

Palmieri EM; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy.
Spera I; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy.
Menga A; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy.
Infantino V; Department of Science, University of Basilicata, Potenza, Italy.
Porcelli V; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy.
Iacobazzi V; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy; Center of Excellence in Comparative Genomics, University of Bari "Aldo Moro", Bari, Italy; CNR Institute of Biomembranes and Bioenergetics, Bari, Italy.
Pierri CL; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy.
Hooper DC; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, USA; Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, USA.
Palmieri F; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy; Center of Excellence in Comparative Genomics, University of Bari "Aldo Moro", Bari, Italy. Electronic address: ferdinando.palmieri@uniba.it.
Castegna A; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Bari, Italy; Center of Excellence in Comparative Genomics, University of Bari "Aldo Moro", Bari, Italy. Electronic address: alessandra.castegna@uniba.it.

Biochim Biophys Acta ; 1847(8): 729-38, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25917893

Assuntos

Proteínas de Transporte/metabolismo; Ácido Cítrico/metabolismo; Ativação de Macrófagos/fisiologia; Malatos/metabolismo; Mitocôndrias/metabolismo; NADP/metabolismo; Acetilação; Transporte Biológico; Western Blotting; Células Cultivadas; Citosol/efeitos dos fármacos; Citosol/metabolismo; Glucose/metabolismo; Humanos; Imunoprecipitação; Interferon gama/farmacologia; Ativação de Macrófagos/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Sirtuína 3/metabolismo; Fator de Necrose Tumoral alfa/farmacologia; Células U937

Palavras-chave

Acetylation; Citrate; Inflammation; Macrophage; Mitochondrial citrate carrier; Post-translational modification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Ácido Cítrico / Ativação de Macrófagos / Malatos / Mitocôndrias / NADP Limite: Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2015 Tipo de documento: Article

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