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Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.
Moreira, Wilfried; Ngan, Grace J Y; Low, Jian Liang; Poulsen, Anders; Chia, Brian C S; Ang, Melgious J Y; Yap, Amelia; Fulwood, Justina; Lakshmanan, Umayal; Lim, Jolander; Khoo, Audrey Y T; Flotow, Horst; Hill, Jeffrey; Raju, Ravikiran M; Rubin, Eric J; Dick, Thomas.
Afiliação
  • Moreira W; Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore.
  • Ngan GJ; Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore.
  • Low JL; Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore.
  • Poulsen A; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Chia BC; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Ang MJ; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Yap A; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Fulwood J; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Lakshmanan U; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Lim J; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Khoo AY; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Flotow H; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Hill J; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Raju RM; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
  • Rubin EJ; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
  • Dick T; Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore thomas_dick@nuhs.edu.sg.
mBio ; 6(3): e00253-15, 2015 May 05.
Article em En | MEDLINE | ID: mdl-25944857
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Serina Endopeptidases / Bortezomib / Mycobacterium / Antituberculosos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: MBio Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Serina Endopeptidases / Bortezomib / Mycobacterium / Antituberculosos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: MBio Ano de publicação: 2015 Tipo de documento: Article