Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast.
J Biomed Opt
; 20(5): 50504, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-26008874
ABSTRACT
Lymph nodes play a central role in metastatic cancer spread and are a key clinical assessment target. Abnormal node vascularization, morphology, and size may be indicative of disease but can be difficult to visualize with sufficient accuracy using existing clinical imaging modalities. To explore the potential utility of photoacoustic imaging for the assessment of lymph nodes, images of ex vivo samples were obtained at multiple wavelengths using a high-resolution three-dimensional photoacoustic scanner. These images showed that hemoglobin based contrast reveals nodal vasculature and lipid-based contrast reveals the exterior node size, shape, and boundary integrity. These two sources of complementary contrast may allow indirect observation of cancer, suggesting a future role for photoacoustic imaging as a tool for the clinical assessment of lymph nodes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas
/
Imagem Molecular
/
Técnicas Fotoacústicas
/
Lipídeos
/
Linfonodos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Biomed Opt
Ano de publicação:
2015
Tipo de documento:
Article