Assessment of renal allograft function early after transplantation with isotropic resolution diffusion tensor imaging.
Eur Radiol
; 26(2): 567-75, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26017738
ABSTRACT
OBJECTIVES:
To investigate the value of diffusion tensor imaging (DTI) and tractography in renal allografts at the early stage after kidney transplantation.METHODS:
This study was approved by the institutional ethical review committee, and written informed consent was obtained. A total of 54 renal allograft recipients 2-3 weeks after transplantation and 26 age-matched healthy volunteers underwent renal DTI with a 3.0-T magnetic resonance imaging (MRI) system. Recipients were divided into three groups according to the estimated glomerular filtration rate (eGFR). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the cortex and medulla were measured and compared among the groups. Whole-kidney tractography was performed. Correlation of eGFR with diffusion parameters was evaluated.RESULTS:
In allografts with stable function, the medullary ADC was higher and the cortical FA was lower (p < 0.001) than in healthy kidneys. The cortical ADC, medullary ADC and FA decreased as the allograft function declined, and with a positive correlation with eGFR (p < 0.001); cortical FA did not. Tractography demonstrated a decrease of tract density in impaired functional allografts.CONCLUSIONS:
Renal DTI produces reliable results to assess renal allograft function at the early stage after transplantation. KEY POINTS ⢠DTI and tractography can evaluate renal allograft function at an early stage ⢠Medullary FA, cortical and medullary ADC can effectively evaluate allograft function ⢠Medullary FA, cortical and medullary ADC are correlated with eGFR in renal allografts ⢠Medullary ADC increased and cortical FA decreased in stable allografts compared to control subjects ⢠Medullary FA, cortical and medullary ADC decreased and allograft function declined.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Transplante de Rim
/
Imagem de Difusão por Ressonância Magnética
/
Imagem de Tensor de Difusão
/
Rim
Aspecto:
Ethics
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Ano de publicação:
2016
Tipo de documento:
Article