Acute exacerbation of rheumatoid interstitial lung disease during the maintenance therapy with certolizumab pegol.
Mod Rheumatol
; 27(6): 1079-1082, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-26044288
We report a case involving a 68-year-old woman with rheumatoid arthritis (RA) with acute exacerbated interstitial lung disease (ILD) during certolizumab pegol maintenance therapy. She recovered quickly with steroid pulse therapy and was discharged without deterioration of basal pulmonary function. Immunoblot analysis demonstrated the circulating cleaved interleukin-1ß at the phase of acute exacerbation of RA-associated ILD (RA-ILD) in this patient. The findings from this case suggested that the Nod-like receptor pyrin domain-containing protein 3 inflammasome is implicated in acute RA-ILD exacerbation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
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Doenças Pulmonares Intersticiais
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Antirreumáticos
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Certolizumab Pegol
Limite:
Aged
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Female
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Humans
Idioma:
En
Revista:
Mod Rheumatol
Ano de publicação:
2017
Tipo de documento:
Article