CSF-1/CSF-1R targeting agents in clinical development for cancer therapy.
Curr Opin Pharmacol
; 23: 45-51, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26051995
ABSTRACT
Macrophage infiltration has been identified as an independent poor prognostic factor for several cancer entities. In mouse tumor models macrophages orchestrate various tumor-promoting processes. This observation sparked an interest to therapeutically target these plastic innate immune cells. To date, blockade of colony stimulating factor-1 or its receptor represents the only truly selective approach to manipulate macrophages in cancer patients. Here, we discuss the currently available information on efficacy and safety of various CSF-1/CSF-1R inhibitors in cancer patients and highlight potential combination partners emerging from preclinical studies while considering the differences between mouse and human macrophage biology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator Estimulador de Colônias de Macrófagos
/
Sistemas de Liberação de Medicamentos
/
Receptor de Fator Estimulador de Colônias de Macrófagos
/
Macrófagos
/
Neoplasias
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Ano de publicação:
2015
Tipo de documento:
Article