Epstein-Barr virus latent membrane protein 2A mediated activation of Sonic Hedgehog pathway induces HLA class Ia downregulation in gastric cancer cells.
Virology
; 484: 22-32, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26057149
ABSTRACT
One of the immune evasion strategies manifested by malignant cells is the downregulation of the Human Leukocyte Antigen (HLA). HLA Class I (HLA- A, -B, -C) present endogenous peptides including viral and tumor antigens to cytotoxic T lymphocytes for immune mediated destruction. We have found the Epstein Barr Virus (EBV) Latent Membrane Protein 2A (LMP2A) to be responsible for this HLA downregulation in gastric cancer cells. Our results further indicate the Sonic Hedgehog pathway; primarily Gli1 to bring about the LMP2A mediated decrease in HLA expression.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
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Regulação para Baixo
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Proteínas da Matriz Viral
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Herpesvirus Humano 4
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Células Epiteliais
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Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2015
Tipo de documento:
Article