Effect of retinyl acetate on nuclear proteins in rabbit liver.

1. Retinyl acetate injected intraperitoneally to adult rabbits fed on standard diet caused detectable changes in the polyacrylamide gel patterns of liver nucleoplasmic and 0.35 M NaCl-soluble chromatin proteins. 2. Both histones and non-histone proteins soluble in 5 M urea were not affected in vitamin A-treated animals. 3. It seems that variations in liver nuclear proteins from retinyl acetate-administered rabbits may reflect retinol-dependent alterations in structure and function of their chromatins.