[EPHX1 Tyr113His polymorphism contributes to hepatocellular carcinoma risk: evidfnce from a meta-analysis].
Mol Biol (Mosk)
; 49(2): 351-61, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-26065263
ABSTRACT
To clarify the association between microsomal epoxide hydrolase gene (EPHX1) Tyr113His polymorphism and hepatocellular carcinoma (HCC) risk, a meta-analysis was performed. Overall, EPHX1 Tyr113His polymorphism was associated with increased risk of HCC. Subgroup analyses by status of Hardy-Weinberg equilibrium (HWE) in controls further confirmed this association. Through a literature search, 119 relevant records were identified, and 17 individual case-control studies from 13 publications were finally included, involving a total of 1,480 HCC cases and 2,564 controls. In subgroup analyses, increased associations were found in Asians, Caucasians, hepatitis B virus (HBV)- dominant areas, hepatitis C virus (HCV)-dominant areas, high-rate areas of HCC, and medium-rate areas of HCC, but not in Africans and low-rate areas of HCC, respectively. This meta-analysis suggests that EPHX1 Tyr113His polymorphism contributes to HCC risk.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Carcinoma Hepatocelular
/
Epóxido Hidrolases
/
Neoplasias Hepáticas
/
Proteínas de Neoplasias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
Ru
Revista:
Mol Biol (Mosk)
Ano de publicação:
2015
Tipo de documento:
Article