Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression.
Cell Mol Neurobiol
; 36(1): 113-20, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26084601
ABSTRACT
MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Regulação para Cima
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MicroRNAs
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Fator A de Crescimento do Endotélio Vascular
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Glioma
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Neovascularização Patológica
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cell Mol Neurobiol
Ano de publicação:
2016
Tipo de documento:
Article