Testicular Morphology and Spermatozoid Parameters in Spontaneously Hypertensive Rats Treated with Enalapril.
J Urol
; 194(5): 1498-503, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26087381
ABSTRACT
PURPOSE:
We evaluated testicular morphology and spermatozoid parameters in spontaneously hypertensive rats treated with enalapril. MATERIALS ANDMETHODS:
Spontaneously hypertensive rats were assigned to a hypertensive nontreated group and a hypertensive enalapril treated group. Wistar-Kyoto normotensive rats served as controls. Systolic blood pressure was measured weekly. Spermatozoid concentration, motility and viability were determined in samples collected from the epididymal tail. Testicular morphology was analyzed by morphometric methods. All data were compared using ANOVA and the Tukey post test with p <0.05 considered significant.RESULTS:
Systolic blood pressure in the enalapril treated group was similar to that in controls but lower than in the nontreated group. Sperm concentration in the enalapril treated group was similar to that in controls and greater than in the nontreated group. Testicular vascular volumetric density decreased in the nontreated group while in enalapril treated rats this parameter was similar to that in controls. Volumetric density of the seminiferous epithelium in the enalapril treated group was higher than in the nontreated group and controls, indicating a possibly positive effect of enalapril on spermatogenesis.CONCLUSIONS:
In this animal model hypertension caused morphological changes in the testis and upon spermatozoid production. Enalapril treatment partially protected the testicles from these alterations, restoring normal spermatozoid production.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Testículo
/
Enalapril
/
Hipertensão
/
Infertilidade Masculina
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Urol
Ano de publicação:
2015
Tipo de documento:
Article