HIF hydroxylase pathways in cardiovascular physiology and medicine.
Circ Res
; 117(1): 65-79, 2015 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-26089364
ABSTRACT
Hypoxia inducible factors (HIFs) are α/ß heterodimeric transcription factors that direct multiple cellular and systemic responses in response to changes in oxygen availability. The oxygen sensitive signal is generated by a series of iron and 2-oxoglutarate-dependent dioxygenases that catalyze post-translational hydroxylation of specific prolyl and asparaginyl residues in HIFα subunits and thereby promote their destruction and inactivation in the presence of oxygen. In hypoxia, these processes are suppressed allowing HIF to activate a massive transcriptional cascade. Elucidation of these pathways has opened several new fields of cardiovascular research. Here, we review the role of HIF hydroxylase pathways in cardiac development and in cardiovascular control. We also consider the current status, opportunities, and challenges of therapeutic modulation of HIF hydroxylases in the therapy of cardiovascular disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Sistema Cardiovascular
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Subunidade alfa do Fator 1 Induzível por Hipóxia
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Prolina Dioxigenases do Fator Induzível por Hipóxia
Idioma:
En
Revista:
Circ Res
Ano de publicação:
2015
Tipo de documento:
Article