Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance.
Chem Commun (Camb)
; 51(58): 11587-90, 2015 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-26096645
ABSTRACT
A nanohybrid is assembled by ratiometrically co-loading Pt(IV) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfirinas
/
Pró-Fármacos
/
Fármacos Fotossensibilizantes
/
Compostos de Platina
/
Nanopartículas
/
Hidróxidos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2015
Tipo de documento:
Article