Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.
Hear Res
; 330(Pt B): 213-20, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26119177
ABSTRACT
The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vias Auditivas
/
Percepção Auditiva
/
Transtornos da Percepção Auditiva
/
Transmissão Sináptica
/
Audição
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Hear Res
Ano de publicação:
2015
Tipo de documento:
Article