Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles.
Chem Commun (Camb)
; 51(60): 12028-31, 2015 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-26121049
ABSTRACT
Silica and iron oxide nanoparticles with sizes ranging from 6 to 40 nm were functionalized with trehalose. The trehalose-conjugated nanoparticles showed strong interactions with Mycobacterium smegmatis (M. smegmatis) and minimal interactions with macrophage (RAW 264.7) or A549 cells. In addition, trehalose-conjugated silica nanoparticles selectively interacted with M. smegmatis on M. smegmatis-treated A549 cells, demonstrating high potential of trehalose in developing targeted therapy for treating mycobacterial infection.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Trealose
/
Mycobacterium smegmatis
/
Nanopartículas
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Infecções por Mycobacterium não Tuberculosas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2015
Tipo de documento:
Article