Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice.
Exp Anim
; 64(4): 375-82, 2015.
Article
em En
| MEDLINE
| ID: mdl-26134357
ABSTRACT
Helicobacter sp. MIT 01-6451 has been detected in SPF mice kept in Japan. To characterize strain MIT 01-6451, its infection route during fetal and neonatal life and effects on pregnancy were investigated using immunocompetent and immunodeficient mouse strains (BALB/c, C57BL/6, and SCID). MIT 01-6451 was detected in the uterus, vagina, and mammary glands of 50% of infected SCID mice, whereas these tissues were all negative in immunocompetent mice. No fetal infections with MIT 01-6451 were detected at 16-18 days after pregnancy in any mouse strain. In newborn mice, MIT 01-6451 was detected in intestinal tissue of C57BL/6 and SCID mice at 9-11 days after birth, but not in BALB/c mice. The IgA and IgG titers to MIT 01-6451 in sera of C57BL/6 female mice were significantly lower than those of BALB/c mice. Although no significant differences in the number of newborns per litter were observed between MIT 01-6451-infected and MIT 01-6451-free dams, the birth rate was lower in infected SCID mice than in control SCID mice. The present results indicated that MIT 01-6451 infects newborn mice after birth rather than by vertical transmission to the fetus via the placenta and that MIT 01-6451 infection shows opportunistically negative effects on the birth rate. In addition, the maternal immune response may affect infection of newborn mice with MIT 01-6451 through breast milk.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Doenças dos Roedores
/
Infecções por Helicobacter
/
Helicobacter
/
Transmissão de Doença Infecciosa
/
Feto
/
Animais de Laboratório
/
Animais Recém-Nascidos
Limite:
Animals
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Exp Anim
Ano de publicação:
2015
Tipo de documento:
Article