Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies.
Oncoimmunology
; 4(7): e1005523, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26140230
ABSTRACT
We have developed a highly versatile platform for the systematic retrieval of T-cell receptors (TCRs) from single-antigen-reactive T cells and for characterization of their function and specificity. This approach enables rapid extraction of multiple TCRs from repertoires in individuals and not only broadens the diversity of TCRs suitable for clinical use, but also sets the stage for actively personalized immunotherapeutic strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Oncoimmunology
Ano de publicação:
2015
Tipo de documento:
Article