Lead Exposure Impairs Hippocampus Related Learning and Memory by Altering Synaptic Plasticity and Morphology During Juvenile Period.

Wang, Tao; Guan, Rui-Li; Liu, Ming-Chao; Shen, Xue-Feng; Chen, Jing Yuan; Zhao, Ming-Gao; Luo, Wen-Jing

Wang, Tao; Guan, Rui-Li; Liu, Ming-Chao; Shen, Xue-Feng; Chen, Jing Yuan; Zhao, Ming-Gao; Luo, Wen-Jing.

Afiliação

Wang T; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, China.
Guan RL; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, China.
Liu MC; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, China.
Shen XF; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, China.
Chen JY; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, China.
Zhao MG; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, China. minggao@fmmu.edu.cn.
Luo WJ; Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, The Fourth Military Medical University, Xi'an, 710032, China. luowenj@fmmu.edu.cn.

Mol Neurobiol ; 53(6): 3740-3752, 2016 08.

Article em En | MEDLINE | ID: mdl-26141123

Assuntos

Hipocampo/patologia; Hipocampo/fisiopatologia; Chumbo/toxicidade; Memória/fisiologia; Plasticidade Neuronal/fisiologia; Animais; Ansiedade/patologia; Ansiedade/fisiopatologia; Comportamento Animal; Condicionamento Psicológico/efeitos dos fármacos; Espinhas Dendríticas/efeitos dos fármacos; Espinhas Dendríticas/patologia; Regulação para Baixo/efeitos dos fármacos; Medo; Ácido Glutâmico/metabolismo; Hipocampo/crescimento & desenvolvimento; Potenciais Pós-Sinápticos Inibidores/efeitos dos fármacos; Potenciação de Longa Duração/efeitos dos fármacos; Masculino; Memória/efeitos dos fármacos; Plasticidade Neuronal/efeitos dos fármacos; Fosforilação/efeitos dos fármacos; Terminações Pré-Sinápticas/efeitos dos fármacos; Terminações Pré-Sinápticas/metabolismo; Ratos Sprague-Dawley; Receptores de AMPA/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo; Transmissão Sináptica/fisiologia

Palavras-chave

Dendritic spine; Fear-conditioned memory; Hippocampus; Lead (Pb); Synaptic plasiticity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipocampo / Chumbo / Memória / Plasticidade Neuronal Limite: Animals Idioma: En Revista: Mol Neurobiol Ano de publicação: 2016 Tipo de documento: Article

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