Granuloma Annulare.
Dermatol Clin
; 33(3): 315-29, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26143416
ABSTRACT
Granuloma annulare (GA) is a noninfectious granulomatous skin condition that can present with a variety of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Although the mechanism underlying development of GA is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic associations with diabetes, thyroid disorders, lipid abnormalities, malignancy, and infection are described in atypical GA. Treatment is divided into localized skin-directed therapies and systemic immunomodulatory or immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of potential side effects, and patient preference.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Interferon gama
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Fator de Necrose Tumoral alfa
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Granuloma Anular
/
Interleucina-12
Limite:
Humans
Idioma:
En
Revista:
Dermatol Clin
Ano de publicação:
2015
Tipo de documento:
Article