Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1ß secretion in response to anti-MPO antibodies.

O'Brien, Eóin C; Abdulahad, Wayel H; Rutgers, Abraham; Huitema, Minke G; O'Reilly, Vincent P; Coughlan, Alice M; Harrington, Mark; Heeringa, Peter; Little, Mark A; Hickey, Fionnuala B

O'Brien, Eóin C; Abdulahad, Wayel H; Rutgers, Abraham; Huitema, Minke G; O'Reilly, Vincent P; Coughlan, Alice M; Harrington, Mark; Heeringa, Peter; Little, Mark A; Hickey, Fionnuala B.

Afiliação

O'Brien EC; Trinity Health Kidney Centre, Department of Clinical Medicine, Trinity College Dublin, St. James' Hospital Campus, Dublin 8, Ireland.
Abdulahad WH; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Rutgers A; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Huitema MG; Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
O'Reilly VP; Trinity Health Kidney Centre, Department of Clinical Medicine, Trinity College Dublin, St. James' Hospital Campus, Dublin 8, Ireland.
Coughlan AM; Trinity Health Kidney Centre, Department of Clinical Medicine, Trinity College Dublin, St. James' Hospital Campus, Dublin 8, Ireland.
Harrington M; Trinity Health Kidney Centre, Department of Clinical Medicine, Trinity College Dublin, St. James' Hospital Campus, Dublin 8, Ireland.
Heeringa P; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Little MA; Trinity Health Kidney Centre, Department of Clinical Medicine, Trinity College Dublin, St. James' Hospital Campus, Dublin 8, Ireland.
Hickey FB; Trinity Health Kidney Centre, Department of Clinical Medicine, Trinity College Dublin, St. James' Hospital Campus, Dublin 8, Ireland.

Sci Rep ; 5: 11888, 2015 Jul 07.

Article em En | MEDLINE | ID: mdl-26149790

Assuntos

Anticorpos Anticitoplasma de Neutrófilos/imunologia; Autoantígenos/metabolismo; Monócitos/metabolismo; Peroxidase/imunologia; Vasculite/patologia; Adolescente; Adulto; Idoso; Anticorpos Monoclonais/imunologia; Autoantígenos/imunologia; Progressão da Doença; Feminino; Citometria de Fluxo; Proteínas Ligadas por GPI/metabolismo; Glomerulonefrite/metabolismo; Glomerulonefrite/patologia; Humanos; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Interleucina-8/metabolismo; Isoantígenos/metabolismo; Masculino; Pessoa de Meia-Idade; Monócitos/imunologia; Mieloblastina/imunologia; Neutrófilos/imunologia; Neutrófilos/metabolismo; Receptores de Superfície Celular/metabolismo; Receptores Fc/química; Receptores Fc/metabolismo; Receptores de IgG/química; Receptores de IgG/metabolismo; Vasculite/metabolismo; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoantígenos / Vasculite / Monócitos / Peroxidase / Anticorpos Anticitoplasma de Neutrófilos Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2015 Tipo de documento: Article

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