Hematopoietic Cell and Renal Transplantation in Plasma Cell Dyscrasia Patients.
Cell Transplant
; 25(6): 995-1005, 2016.
Article
em En
| MEDLINE
| ID: mdl-26160700
ABSTRACT
Gammopathies, multiple myeloma, and amyloidosis are plasma dyscrasias characterized by clonal proliferation and immunoglobulin overproduction. Renal impairment is the most common and serious complication with an incidence of 20-30% patients at the diagnosis. Kidney transplant has not been considered feasible in the presence of plasma dyscrasias because the immunosuppressive therapy may increase the risk of neoplasia progression, and paraproteins may affect the graft. However, recent advances in clinical management of multiple myeloma and other gammopathies allow considering kidney transplant as a possible alternative to dialysis. Numerous evidence indicates the direct relationship between hematological remission and renal function restoring. The combination of kidney and hematopoietic cell transplant has been reported as a promising approach to reestablish end-organ function and effectively treat the underlying disease. This review describes current protocols used to perform kidney transplantation in patients with plasma dyscrasias.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paraproteinemias
/
Transplante de Rim
/
Transplante de Células-Tronco Hematopoéticas
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
Cell Transplant
Ano de publicação:
2016
Tipo de documento:
Article