Evaluation of safety of iridoids rich fraction from Valeriana jatamansi Jones: Acute and sub-chronic toxicity study in mice and rats.

Xu, Keke; Lin, Yu; Zhang, Ruitong; Lan, Ming; Chen, Chaoyong; Li, Shaohua; Zuo, Changying; Chen, Chang; Zhang, Tiane; Yan, Zhiyong

Xu, Keke; Lin, Yu; Zhang, Ruitong; Lan, Ming; Chen, Chaoyong; Li, Shaohua; Zuo, Changying; Chen, Chang; Zhang, Tiane; Yan, Zhiyong.

Afiliação

Xu K; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Lin Y; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Zhang R; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Lan M; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Chen C; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Li S; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Zuo C; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Chen C; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhang T; School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yan Z; School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. Electronic address: yzhiy@swjtu.edu.cn.

J Ethnopharmacol ; 172: 386-94, 2015 Aug 22.

Article em En | MEDLINE | ID: mdl-26164073

Assuntos

Iridoides/toxicidade; Extratos Vegetais/toxicidade; Valeriana/química; Animais; Relação Dose-Resposta a Droga; Feminino; Iridoides/administração & dosagem; Iridoides/isolamento & purificação; Masculino; Dose Máxima Tolerável; Medicina Tradicional Chinesa; Camundongos; Nível de Efeito Adverso não Observado; Extratos Vegetais/administração & dosagem; Ratos; Ratos Sprague-Dawley; Testes de Toxicidade Aguda; Testes de Toxicidade Subcrônica

Palavras-chave

Acute toxicity; Iridoids rich fraction; Mice; Rat; Sub-chronic toxicity; Valeriana jatamansi Jones

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valeriana / Extratos Vegetais / Iridoides Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2015 Tipo de documento: Article

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