ACC1, acetyl-CoA carboxylase 1; BSA, bovine serum albumin; DGAT, diacylglycerol acyltransferase; DMEM, Dulbecco's Modified Eagle Medium; EHC, euglycemic hyperinsulinemic clamp; FABP4, fatty acid binding protein 4; FAS, fatty acid synthase; FBS, fetal bovine serum; FFA, free fatty acids; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GH, growth hormone; GHD, growth hormone deficiency; GLUT4, glucose transporter 4; HSL, hormone sensitive lipase; IGF-1, insulin-like growth factor 1; IRS1, insulin receptor substrate 1; MRI, magnetic resonance imaging; PPARGC1A, peroxisome proliferator-activated receptor 1 gamma coactivator 1 α; RPL13A, ribosomal protein L13a; TG, triglycerides; ZAG, zinc-α2-glycoprotein.; adipocyte size; adipose tissue; glucose tolerance; growth hormone deficiency; growth hormone replacement therapy; insulin sensitivity; lipolysis; oGTT, oral glucose tolerance test; rhGH, recombinant human growth hormone