[Telomeric fusion of the chromosomes in cells with micronuclei during the subsequent incorporation into the DNA of thymidine halogenated analogs]. / Telomernoe sliianie khromosom v kletkakh s mikroiadrami pri posledovatel'nom vkliuchenii v DNK galogenovykh analogov timidina.
Tsitologiia
; 31(10): 1242-4, 1989 Oct.
Article
em Ru
| MEDLINE
| ID: mdl-2617673
ABSTRACT
As was shown elsewhere among halogenated analogs of thymidine there exist strong (5-chlorodeoxyuridine, 5-ChldU) and weak (5-iododeoxyuridine, 5-IdU) inducers of dicentric chromosomes in cells with micronuclei. Since from colcemid administration to the moment of fixation two cycles of replication are passed, a study was made of the pattern of induction of dicentric chromosomes under subsequent administration of 5-ChldU and 5-IdU, and the other way round. It was shown that the pattern of induction of dicentric chromosomes was strong or weak, and depended on the fact which analog was administered in the first S-period.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timidina
/
DNA
/
Cromossomos
/
Micronúcleos com Defeito Cromossômico
Limite:
Animals
Idioma:
Ru
Revista:
Tsitologiia
Ano de publicação:
1989
Tipo de documento:
Article