Multicomponent Strategy to Pyrazolo[3,4-e]indolizine Derivatives under Microwave Irradiation.
J Org Chem
; 80(16): 8435-42, 2015 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-26193420
ABSTRACT
A simple and efficient one-pot construction of pyrazolo[3,4-e]indolizine derivatives via a diethylamine-catalyzed three-component domino reaction of arylglyoxals, cyclic 1,3-diones, and 5-aminopyrazoles under microwave irradiation is described. In this one-pot transformation, seven bonds and two new rings are efficiently formed. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization or chromatography purification methods.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Dietilaminas
/
Indolizinas
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2015
Tipo de documento:
Article