Synthesis and Antimicrobial Activities of 3-Methyl-ß-Carboline Derivatives.
Nat Prod Commun
; 10(6): 899-902, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26197512
The ß-carboline alkaloids possess a diverse range of important biochemical effects and pharmacological properties. Sixteen 3-methyl-ß-carboline derivatives were synthesized from indole formaldehyde and nitroethane via the Henry reaction, LAH/THF reduction, the Pictet-Spengler reaction and Pd/C/xylene oxidation, including four 1-substituted and twelve 9-substituted 3-methyl- ß-carboline derivatives. The structures of all the derivatives were confirmed by 1H NMR, 13C NMR and ESI-MS. Most of these 3-methyl-ß-carboline derivatives showed some antibacterial activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbolinas
/
Antibacterianos
Idioma:
En
Revista:
Nat Prod Commun
Ano de publicação:
2015
Tipo de documento:
Article