How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets.

Peixoto, Lucia; Risso, Davide; Poplawski, Shane G; Wimmer, Mathieu E; Speed, Terence P; Wood, Marcelo A; Abel, Ted

Peixoto, Lucia; Risso, Davide; Poplawski, Shane G; Wimmer, Mathieu E; Speed, Terence P; Wood, Marcelo A; Abel, Ted.

Afiliação

Peixoto L; Department of Biology, University of Pennsylvania, Smilow Center for Translational Research, Room 10-170, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104-6168, USA.
Risso D; Division of Biostatistics, School of Public Health, University of California, Berkeley, 344 Li Ka Shing Center, #3370, Berkeley, CA 94720-3370, USA.
Poplawski SG; Department of Biology, University of Pennsylvania, Smilow Center for Translational Research, Room 10-170, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104-6168, USA.
Wimmer ME; Department of Biology, University of Pennsylvania, Smilow Center for Translational Research, Room 10-170, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104-6168, USA.
Speed TP; Department of Statistics, University of California, Berkeley, Department of Mathematics and Statistics, The University of Melbourne, Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Australia.
Wood MA; University of California, Irvine, Department of Neurobiology and Behavior, USA.
Abel T; Department of Biology, University of Pennsylvania, Smilow Center for Translational Research, Room 10-170, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104-6168, USA abele@sas.upenn.edu.

Nucleic Acids Res ; 43(16): 7664-74, 2015 Sep 18.

Article em En | MEDLINE | ID: mdl-26202970

Assuntos

Perfilação da Expressão Gênica/métodos; Análise de Sequência de RNA/métodos; Animais; Variação Genética; Masculino; Camundongos Endogâmicos C57BL; Neurociências/métodos; Reprodutibilidade dos Testes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise de Sequência de RNA / Perfilação da Expressão Gênica Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2015 Tipo de documento: Article

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