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Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.
Chu, Hin; Zhou, Jie; Wong, Bosco Ho-Yin; Li, Cun; Chan, Jasper Fuk-Woo; Cheng, Zhong-Shan; Yang, Dong; Wang, Dong; Lee, Andrew Chak-Yiu; Li, Chuangen; Yeung, Man-Lung; Cai, Jian-Piao; Chan, Ivy Hau-Yee; Ho, Wai-Kuen; To, Kelvin Kai-Wang; Zheng, Bo-Jian; Yao, Yanfeng; Qin, Chuan; Yuen, Kwok-Yung.
Afiliação
  • Chu H; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.
  • Zhou J; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.
  • Wong BH; Department of Microbiology.
  • Li C; Department of Microbiology.
  • Chan JF; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.
  • Cheng ZS; Department of Microbiology.
  • Yang D; Department of Microbiology.
  • Wang D; Department of Microbiology.
  • Lee AC; Department of Microbiology.
  • Li C; Department of Microbiology.
  • Yeung ML; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.
  • Cai JP; Department of Microbiology.
  • Chan IH; Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.
  • Ho WK; Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.
  • To KK; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.
  • Zheng BJ; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.
  • Yao Y; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.
  • Qin C; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.
  • Yuen KY; State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, China.
J Infect Dis ; 213(6): 904-14, 2016 Mar 15.
Article em En | MEDLINE | ID: mdl-26203058
Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Apoptose / Coronavírus da Síndrome Respiratória do Oriente Médio Limite: Animals / Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Apoptose / Coronavírus da Síndrome Respiratória do Oriente Médio Limite: Animals / Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2016 Tipo de documento: Article