Influence of the nanoprecipitation conditions on the supramolecular structure of squalenoyled nanoparticles.
Eur J Pharm Biopharm
; 96: 89-95, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26210010
ABSTRACT
Hydrophobic organic compounds dissolved in a polar solvent can self-assemble into nanoparticles (NPs) upon nanoprecipitation into water. In the present study, we have investigated the structure of squalenacetyl-adenosine (SQAc-Ad) nanoparticles which were previously found to exhibit impressive neuroprotective activity. When obtained by nanoprecipitation of a SQAc-Ad ethanolic solution into water, two different supramolecular organizations of SQAc-Ad NPs were evidenced, depending on the water-to-ethanol volume ratio. It has been shown that a fraction of the solvent remained associated with the NPs, despite prolonged evaporation under reduced pressure after nanoprecipitation, and that this residual solvent dramatically affected their structure. This study points to the importance of being in the "Ouzo" region to minimize the amount and effect of residual solvent and to control the structure of NPs.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esqualeno
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Desenho de Fármacos
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Adenosina
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Sistemas de Liberação de Medicamentos
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Fármacos Neuroprotetores
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Nanopartículas
Idioma:
En
Revista:
Eur J Pharm Biopharm
Ano de publicação:
2015
Tipo de documento:
Article