The effect of adjuvant chemotherapy on plasma TAT and F 1+2 levels in patients with breast cancer.
Biomed Pharmacother
; 73: 19-23, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26211577
ABSTRACT
INTRODUCTION:
Increased thromboembolic disorders and chemotherapy-induced thromboembolic events are well known phenomena in patients with breast cancer. Antithrombin III (AT III) inactivates thrombin, resulting in increased thrombin-antithrombin (TAT) levels. Activated factor X cleaves prothrombin and thrombin, resulting in increased levels of prothrombin fragment 1+2 (F 1+2). Increased TAT and F 1+2 levels show coagulation activation. The aim of this study was to examine plasma levels of TAT and F 1+2 and the effect of anthracycline-based chemotherapy on plasma TAT and F 1+2 in patients with operable breast cancer. MATERIALS ANDMETHODS:
Seventy patients and 30 age-matched healthy controls were enrolled. Levels of TAT and F 1+2 were investigated before and after adjuvant chemotherapy. Basal levels (pre-chemotherapy) of TAT and F 1+2 in patients were compared with those in healthy controls and patient levels after 3 cycles of chemotherapy. Levels of TAT and F 1+2 were determined using the ELISA method.RESULTS:
TAT and d-dimer levels were significantly higher in patients, (P 0.02 and P<0.001, respectively). Post-chemotherapy F 1+2 levels were higher than basal levels (P 0.02). F 1+2 levels were higher in patients, although the difference was not statistically significant (P 0.52). There was no difference between basal and post-chemotherapy TAT levels.DISCUSSION:
In conclusion, while higher post-chemotherapy F 1+2 levels suggest that the cumulative effect of chemotherapy increases the risk of thrombosis, TAT and d-dimer levels indicate that the effect of the cancer further increases the risk of thrombosis in patients with operable breast cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Peptídeo Hidrolases
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Neoplasias da Mama
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Biomarcadores Tumorais
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Biomed Pharmacother
Ano de publicação:
2015
Tipo de documento:
Article