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Functional Effects of WNT1-Inducible Signaling Pathway Protein-1 on Bronchial Smooth Muscle Cell Migration and Proliferation in OVA-Induced Airway Remodeling.
Yang, Mingjin; Du, Yuejun; Xu, Zhibo; Jiang, Youfan.
Afiliação
  • Yang M; Respiratory Diseases Laboratory, Chengdu Second People's Hospital, Chengdu, China.
  • Du Y; , No. 10, Qingyun South Street, Chengdu, 610017, China.
  • Xu Z; Respiratory Diseases Laboratory, Chengdu Second People's Hospital, Chengdu, China.
  • Jiang Y; , No. 10, Qingyun South Street, Chengdu, 610017, China.
Inflammation ; 39(1): 16-29, 2016 Feb.
Article em En | MEDLINE | ID: mdl-26242865
Upregulation of WISP1 has been demonstrated in lung remodeling. Moreover, it has been recently found that some signaling components of WNT pathway can activate GSK3ß signaling to mediate remodeling of airway smooth muscle (ASM) in asthma. Therefore, we hypothesized that WISP1, a signaling molecule downstream of the WNT signaling pathway, is involved in PI3K/GSK3ß signaling to mediate ASM remodeling in asthma. Our results showed that WISP1 depletion partly suppressed OVA-induced ASM hypertrophy in vivo. In vitro, WISP1 could induce hBSMC hypertrophy and proliferation, accompanied by upregulation of levels of PI3K, p-Akt, p-GSK3ß, and its own expression. TGF-ß treatment could increase expression of PI3K, p-Akt, p-GSK3ß, and WISP1. SH-5 treatment could partly suppress TGF-ß-induced hypertrophy and proliferation of hBSMC, and depress expression of p-GSK3ß and WISP1. In conclusion, WISP1 may be a potential inducer of ASM proliferation and hypertrophy in asthma. The pro-remodeling effect of WISP1 is likely due to be involved in PI3K-GSK3ß-dependent noncanonical TGF-ß signaling.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Movimento Celular / Proteínas Proto-Oncogênicas / Miócitos de Músculo Liso / Proliferação de Células / Proteínas de Sinalização Intercelular CCN / Glicogênio Sintase Quinase 3 beta Limite: Animals / Humans / Male Idioma: En Revista: Inflammation Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Movimento Celular / Proteínas Proto-Oncogênicas / Miócitos de Músculo Liso / Proliferação de Células / Proteínas de Sinalização Intercelular CCN / Glicogênio Sintase Quinase 3 beta Limite: Animals / Humans / Male Idioma: En Revista: Inflammation Ano de publicação: 2016 Tipo de documento: Article