Effect of circadian variability in frequency of premature ventricular complexes on left ventricular function.
Heart Rhythm
; 13(1): 98-102, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26247319
ABSTRACT
BACKGROUND:
Frequent idiopathic premature ventricular complexes (PVCs) can result in a reversible form of cardiomyopathy.OBJECTIVE:
The purpose of this study was to assess the impact of variability in PVC frequency throughout the day on PVC-induced cardiomyopathy.METHODS:
The subjects of this study were 107 consecutive patients (58 men [54%]; mean age 49.7 ± 15.0 years; left ventricular ejection fraction 50.4% ± 11.4%) referred for ablation of frequent PVCs. All patients underwent 24-hour Holter monitoring before the ablation procedure. The circadian variation in PVC burden was determined and correlated with the presence or absence of cardiomyopathy.RESULTS:
A total of 43 patients (40%) had cardiomyopathy. Patients with cardiomyopathy had an ejection fraction of 38.4% ± 6.9%, a higher PVC burden (28.5% ± 11.5% vs 19.5% ± 10.5%; P = .0001), less variability in circadian PVC distribution (coefficient of variation hourly 31.5% ± 21% vs 59.8% ± 32.4%; P = .0001), and more frequent interpolated PVCs (20 patients [47%] vs 15 patients [23%]; P = 0.022), and were more frequently asymptomatic than patients without cardiomyopathy (56% vs 19%; P = .0001). In multivariate analysis, consistency in PVC burden throughout the day was an independent predictor of PVC-induced cardiomyopathy (odds ratio 16.3; 95% confidence interval 1.7-155.3; p = 0.015).CONCLUSION:
In patients with frequent PVCs, consistency in hourly PVC frequency throughout the day is an independent predictor of PVC-induced cardiomyopathy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Ritmo Circadiano
/
Ablação por Cateter
/
Complexos Ventriculares Prematuros
/
Cardiomiopatias
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Heart Rhythm
Ano de publicação:
2016
Tipo de documento:
Article