Blood cells: an historical account of the roles of purinergic signalling.
Purinergic Signal
; 11(4): 411-34, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-26260710
ABSTRACT
The involvement of purinergic signalling in the physiology of erythrocytes, platelets and leukocytes was recognised early. The release of ATP and the expression of purinoceptors and ectonucleotidases on erythrocytes in health and disease are reviewed. The release of ATP and ADP from platelets and the expression and roles of P1, P2Y(1), P2Y(12) and P2X1 receptors on platelets are described. P2Y(1) and P2X(1) receptors mediate changes in platelet shape, while P2Y(12) receptors mediate platelet aggregation. The changes in the role of purinergic signalling in a variety of disease conditions are considered. The successful use of P2Y(12) receptor antagonists, such as clopidogrel and ticagrelor, for the treatment of thrombosis, myocardial infarction and stroke is discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Sanguíneas
/
Transdução de Sinais
/
Receptores Purinérgicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Purinergic Signal
Ano de publicação:
2015
Tipo de documento:
Article