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Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.
van Poelgeest, Eveline P; Hodges, Michael R; Moerland, Matthijs; Tessier, Yann; Levin, Arthur A; Persson, Robert; Lindholm, Marie W; Dumong Erichsen, Kamille; Ørum, Henrik; Cohen, Adam F; Burggraaf, Jacobus.
Afiliação
  • van Poelgeest EP; Centre for Human Drug Research, Leiden, The Netherlands.
  • Hodges MR; Previously Santaris Pharma A/S, now Roche Pharmaceutical Research and Early Development, Innovation Center Copenhagen, Hørsholm, Denmark.
  • Moerland M; Centre for Human Drug Research, Leiden, The Netherlands.
  • Tessier Y; Centre for Human Drug Research, Leiden, The Netherlands.
  • Levin AA; Previously Santaris Pharma A/S, now Roche Pharmaceutical Research and Early Development, Innovation Center Copenhagen, Hørsholm, Denmark.
  • Persson R; Previously Santaris Pharma A/S, now Roche Pharmaceutical Research and Early Development, Innovation Center Copenhagen, Hørsholm, Denmark.
  • Lindholm MW; Previously Santaris Pharma A/S, now Roche Pharmaceutical Research and Early Development, Innovation Center Copenhagen, Hørsholm, Denmark.
  • Dumong Erichsen K; Previously Santaris Pharma A/S, now Roche Pharmaceutical Research and Early Development, Innovation Center Copenhagen, Hørsholm, Denmark.
  • Ørum H; Previously Santaris Pharma A/S, now Roche Pharmaceutical Research and Early Development, Innovation Center Copenhagen, Hørsholm, Denmark.
  • Cohen AF; Centre for Human Drug Research, Leiden, The Netherlands.
  • Burggraaf J; Centre for Human Drug Research, Leiden, The Netherlands.
Br J Clin Pharmacol ; 80(6): 1350-61, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26261033
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso / Pró-Proteína Convertases Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos Antissenso / Pró-Proteína Convertases Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2015 Tipo de documento: Article