Recent developments in the chemistry of quinazolinone alkaloids.
Org Biomol Chem
; 13(36): 9336-52, 2015 Sep 28.
Article
em En
| MEDLINE
| ID: mdl-26278395
ABSTRACT
Quinazolinones, an important class of fused heterocyclic alkaloids has attracted high attention in organic and medicinal chemistry due to their significant and wide range of biological activities. There are approximately 150 naturally occurring quinazolinone alkaloids known till 2005. Several new quinazolinone alkaloids (â¼55) have been isolated in the last decade. Natural quinazolinones with exotic structural features and remarkable biological activities have incited a lot of activities in the synthetic community towards the development of new synthetic strategies and approaches for the total synthesis of quinazolinone alkaloids. This review is focused on these advances in the chemistry of quinazolinone alkaloids in the last decade. This article covers the newly isolated quinazolinone natural products with their biological activities and the recently reported total syntheses of quinazolinone alkaloids from 2006 to 2015.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alcaloides
/
Quinazolinonas
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2015
Tipo de documento:
Article