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Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets.
Neumann, Terrence S; Span, Elise A; Kalous, Kelsey S; Bongard, Robert; Gastonguay, Adam; Lepley, Michael A; Kutty, Raman G; Nayak, Jaladhi; Bohl, Chris; Lange, Rachel G; Sarker, Majher I; Talipov, Marat R; Rathore, Rajendra; Ramchandran, Ramani; Sem, Daniel S.
Afiliação
  • Neumann TS; Department of Chemistry and Biochemistry, Texas Wesleyan University, 1201 Wesleyan Ave., Fort Worth, TX, 76105, USA. tneumann@txwes.edu.
  • Span EA; Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, and School of Pharmacy, Concordia University of Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA. tneumann@txwes.edu.
  • Kalous KS; Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, and School of Pharmacy, Concordia University of Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA. elise.span@gmail.com.
  • Bongard R; Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, and School of Pharmacy, Concordia University of Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA. kekalous@mcw.edu.
  • Gastonguay A; Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, and School of Pharmacy, Concordia University of Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA. Robert.bongard@cuw.edu.
  • Lepley MA; Department of Pediatrics, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, Milwaukee, WI 53226, USA. agastong@gmail.com.
  • Kutty RG; Department of Pediatrics, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, Milwaukee, WI 53226, USA. mlepley@mcw.edu.
  • Nayak J; Department of Pediatrics, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, Milwaukee, WI 53226, USA. rkutty@mcw.edu.
  • Bohl C; Department of Pediatrics, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, Milwaukee, WI 53226, USA. jnayak@mcw.edu.
  • Lange RG; Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, and School of Pharmacy, Concordia University of Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA.
  • Sarker MI; Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, and School of Pharmacy, Concordia University of Wisconsin, 12800 N. Lake Shore Drive, Mequon, WI 53097, USA.
  • Talipov MR; Department of Chemistry, Wehr Chemistry Building, P.O. Box 1881, 535 N. 14th Street, Milwaukee, WI 53201, USA. majher.sarker@ars.usda.gov.
  • Rathore R; Department of Chemistry, Wehr Chemistry Building, P.O. Box 1881, 535 N. 14th Street, Milwaukee, WI 53201, USA. marat.talipov@marquette.edu.
  • Ramchandran R; Department of Chemistry, Wehr Chemistry Building, P.O. Box 1881, 535 N. 14th Street, Milwaukee, WI 53201, USA. rajendra.rathore@marquette.edu.
  • Sem DS; Department of Pediatrics, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, Milwaukee, WI 53226, USA. rramchan@mcw.edu.
BMC Biochem ; 16: 19, 2015 Aug 19.
Article em En | MEDLINE | ID: mdl-26286528
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Inibidores Enzimáticos / Fosfatases de Especificidade Dupla Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: BMC Biochem Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / Inibidores Enzimáticos / Fosfatases de Especificidade Dupla Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: BMC Biochem Ano de publicação: 2015 Tipo de documento: Article