Humanized Mice to Study Human T Cell Development.
Methods Mol Biol
; 1323: 253-72, 2016.
Article
em En
| MEDLINE
| ID: mdl-26294414
ABSTRACT
While in vitro models exist to study human T cell development, they still lack the precise environmental stimuli, such as the exact combination and levels of cytokines and chemokines, that are present in vivo. Moreover, studying the homing of hematopoietic stem (HSC) and progenitor (HPC) cells to the thymus can only be done using in vivo models. Although species-specific differences exist, "humanized" models are generated to circumvent these issues. In this chapter, we focus on the humanized mouse models that can be used to study early T cell development. Models that study solely mature T cells, such as the SCID-PBL (Tary-Lehmann et al., Immunol Today 16529-533) are therefore not discussed here, but have recently been reviewed (Shultz et al., Nat Rev Immunol 12786-798).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
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Linfócitos T
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Diferenciação Celular
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Transplante de Células-Tronco Hematopoéticas
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Xenoenxertos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Methods Mol Biol
Ano de publicação:
2016
Tipo de documento:
Article