How Effective Is First-Trimester Screening for Trisomy 21 Based on Ultrasound Only?
Fetal Diagn Ther
; 39(2): 105-12, 2016.
Article
em En
| MEDLINE
| ID: mdl-26303666
ABSTRACT
OBJECTIVE:
To evaluate the most common first-trimester ultrasound features of fetuses with trisomy 21 (T21) and to examine the screening performance for Down syndrome (DS) using only ultrasound-based protocols. To investigate whether maternal age (MA) has an impact on the efficacy of the ultrasound-based screening methods.METHODS:
In a prospective study, 6,265 patients were examined. Two ultrasound-based risk calculation protocols were applied 'NT' (based on nuchal translucency) and 'NT+' (based on NT and secondary markers).RESULTS:
A total of 5,696 patients were enrolled for analysis; 84 subjects with T21 were identified. Combinations of abnormal ultrasound markers were observed in only 1.2% of euploid fetuses compared to 71.5% of fetuses with T21. Among 17.9% of DS cases with cardiac anomaly, 14.3% comprised atrioventricular septal defects. For a false-positive rate of 3%, the detection rates of T21 were 73.8 and 91.7% for the 'NT' and 'NT+' protocols, respectively. The efficacy of both methods was affected by MA.CONCLUSIONS:
Most of the fetuses with DS demonstrate a combination of ultrasound markers of aneuploidy in the first trimester. The 'NT+' protocol is efficient and provides comparable performance as a combined screening test. It is a valuable method, especially when the access to biochemical analysis is restricted.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Primeiro Trimestre da Gravidez
/
Ultrassonografia Pré-Natal
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Síndrome de Down
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fetal Diagn Ther
Ano de publicação:
2016
Tipo de documento:
Article