Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.

Majumdar, Papiya; Bathula, Chandramohan; Basu, Suparna M; Das, Subhendu K; Agarwal, Rahul; Hati, Santanu; Singh, Ashutosh; Sen, Subhabrata; Das, Benu Brata

Majumdar, Papiya; Bathula, Chandramohan; Basu, Suparna M; Das, Subhendu K; Agarwal, Rahul; Hati, Santanu; Singh, Ashutosh; Sen, Subhabrata; Das, Benu Brata.

Afiliação

Majumdar P; Laboratory of Molecular Biology, Department of Physical Chemistry, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India.
Bathula C; Department of Chemistry, Shiv Nadar University, Post Office Shiv Nadar University, Gautam Buddha Nagar, 201314, Uttar Pradesh, India.
Basu SM; Laboratory of Molecular Biology, Department of Physical Chemistry, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India.
Das SK; Laboratory of Molecular Biology, Department of Physical Chemistry, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India.
Agarwal R; Department of Life Science, Shiv Nadar University, Post Office Shiv Nadar University, Gautam Buddha Nagar, 201314, Uttar Pradesh, India.
Hati S; Department of Chemistry, Shiv Nadar University, Post Office Shiv Nadar University, Gautam Buddha Nagar, 201314, Uttar Pradesh, India.
Singh A; Department of Life Science, Shiv Nadar University, Post Office Shiv Nadar University, Gautam Buddha Nagar, 201314, Uttar Pradesh, India.
Sen S; Department of Chemistry, Shiv Nadar University, Post Office Shiv Nadar University, Gautam Buddha Nagar, 201314, Uttar Pradesh, India. Electronic address: subhabrata.sen@snu.edu.in.
Das BB; Laboratory of Molecular Biology, Department of Physical Chemistry, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India. Electronic address: pcbbd@iacs.res.in.

Eur J Med Chem ; 102: 540-51, 2015 Sep 18.

Article em En | MEDLINE | ID: mdl-26312433

Assuntos

Antineoplásicos/farmacologia; DNA Topoisomerases Tipo I/metabolismo; Desenho de Fármacos; Tioidantoínas/farmacologia; Inibidores da Topoisomerase I/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Células HEK293; Células HeLa; Humanos; Células MCF-7; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade; Tioidantoínas/síntese química; Tioidantoínas/química; Inibidores da Topoisomerase I/síntese química; Inibidores da Topoisomerase I/química

Palavras-chave

Camptothecin; Hydantoin; Leishmania bi-subunit topoisomerase I; Methylfuro[3,4-c]pyridine-3,4(1H,5H)-dione; Thiohydantoin; Topoisomerase I

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioidantoínas / Desenho de Fármacos / DNA Topoisomerases Tipo I / Inibidores da Topoisomerase I / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article

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