Mesoamerican nephropathy: a neglected tropical disease with an infectious etiology?
Microbes Infect
; 17(10): 671-5, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-26320026
ABSTRACT
An outbreak of unexplained and severe kidney disease, "Mesoamerican Nephropathy," in mostly young, male sugar cane workers emerged in Central America in the late 1990's. As a result, an estimated 20,000 individuals have died, to date. Unfortunately, and with great consequence to human life, the etiology of the outbreak has yet to be identified. The sugarcane fields in Chichigalpa, Chinandega, Nicaragua, have been involved in the outbreak, and during our initial investigation, we interviewed case patients who experienced fever, nausea and vomiting, arthralgia, myalgia, headache, neck and back pain, weakness, and paresthesia at the onset of acute kidney disease. We also observed a heavy infestation of rodents, particularly of Sigmodon species, in the sugarcane fields. We hypothesize that infectious pathogens are being shed through the urine and feces of these rodents, and workers are exposed to these pathogens during the process of cultivating and harvesting sugarcane. In this paper, we will discuss the epidemic in the Chichigalpa area, potential pathogens responsible for Mesoamerican Nephropathy, and steps needed in order to diagnose, treat, and prevent future cases from occurring.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Doenças dos Trabalhadores Agrícolas
/
Injúria Renal Aguda
/
Nefrite Intersticial
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
/
Male
País/Região como assunto:
America central
/
Nicaragua
Idioma:
En
Revista:
Microbes Infect
Ano de publicação:
2015
Tipo de documento:
Article