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Organomediated Enantioselective (18)F Fluorination for PET Applications.
Buckingham, Faye; Kirjavainen, Anna K; Forsback, Sarita; Krzyczmonik, Anna; Keller, Thomas; Newington, Ian M; Glaser, Matthias; Luthra, Sajinder K; Solin, Olof; Gouverneur, Véronique.
Afiliação
  • Buckingham F; University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA (UK).
  • Kirjavainen AK; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Kiinamyllynkatu 4-8, 20520 Turku (Finland).
  • Forsback S; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Kiinamyllynkatu 4-8, 20520 Turku (Finland).
  • Krzyczmonik A; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Kiinamyllynkatu 4-8, 20520 Turku (Finland).
  • Keller T; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Kiinamyllynkatu 4-8, 20520 Turku (Finland).
  • Newington IM; GE Healthcare, The Grove Centre, White Lion Road, Amersham, HP7 9LL (UK).
  • Glaser M; GE Healthcare, The Grove Centre, White Lion Road, Amersham, HP7 9LL (UK).
  • Luthra SK; GE Healthcare, The Grove Centre, White Lion Road, Amersham, HP7 9LL (UK).
  • Solin O; Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Kiinamyllynkatu 4-8, 20520 Turku (Finland).
  • Gouverneur V; University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA (UK). veronique.gouverneur@chem.ox.ac.uk.
Angew Chem Int Ed Engl ; 54(45): 13366-9, 2015 Nov 02.
Article em En | MEDLINE | ID: mdl-26360631
ABSTRACT
The first organomediated asymmetric (18)F fluorination has been accomplished using a chiral imidazolidinone and [(18)F]N-fluorobenzenesulfonimide. The method provides access to enantioenriched (18)F-labeled α-fluoroaldehydes (>90% ee), which are versatile chiral (18)F synthons for the synthesis of radiotracers. The utility of this process is demonstrated with the synthesis of the PET (positron emission tomography) tracer (2S,4S)-4-[(18)F]fluoroglutamic acid.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos de Flúor / Tomografia por Emissão de Pósitrons / Halogenação / Glutamatos Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos de Flúor / Tomografia por Emissão de Pósitrons / Halogenação / Glutamatos Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2015 Tipo de documento: Article