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Maternal factors in the origin of infantile hypertrophic pyloric stenosis: A population-based case-control study.
Vermes, Gabor; László, Daniel; Czeizel, Andrew E; Ács, Nándor.
Afiliação
  • Vermes G; Department of Obstetrics and Gynecology, Military Hospital - State Health Centre, Budapest, Hungary.
  • László D; Department of Obstetrics and Gynecology, St. Stephen's Hospital, Budapest, Hungary.
  • Czeizel AE; Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary.
  • Ács N; 2nd Department of Obstetrics and Gynecology, Semmelweis University School of Medicine, Budapest, Hungary.
Congenit Anom (Kyoto) ; 56(2): 65-72, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26394719
In most patients affected by isolated infantile hypertrophic pyloric stenosis (IHPS) the etiology is largely unknown. Thus, the aim of this study was to estimate possible maternal risk factors in the origin of IHPS. The study samples included 241 cases with IHPS, 357 matched controls and 38,151 population controls without any defect in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. Exposures that had been medically recorded in prenatal maternity logbooks during the critical period of IHPS were evaluated separately. The findings of this case-control study suggested that--beyond the well-known robust male excess (85.5%)--maternal hyperthyroidism (OR with 95% CI: 4.17, 1.53-11.38) and oral nalidixic acid treatment (OR with 95% CI: 6.53, 3.03-14.06) associated with a higher risk for IHPS in their children. In conclusion, our findings suggest that cases with IHPS had mothers with a higher proportion of hyperthyroidism and nalidixic acid treatment during pregnancy.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Vigilância da População / Exposição Materna / Estenose Pilórica Hipertrófica Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Congenit Anom (Kyoto) Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Vigilância da População / Exposição Materna / Estenose Pilórica Hipertrófica Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Congenit Anom (Kyoto) Ano de publicação: 2016 Tipo de documento: Article