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Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral center.
Han, Xiao-Feng; He, Xing; Wang, Miao; Xu, Di; Hao, Li-Ping; Liang, Ai-Hua; Zhang, Jun; Zhou, Zhi-Ming.
Afiliação
  • Han XF; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China.
  • He X; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China.
  • Wang M; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China.
  • Xu D; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China.
  • Hao LP; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China.
  • Liang AH; Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, 100029, PR China.
  • Zhang J; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address: zhangjun603@bit.edu.cn.
  • Zhou ZM; R & D Center for Pharmaceuticals, Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address: zzm@bit.edu.cn.
Eur J Med Chem ; 103: 473-87, 2015 Oct 20.
Article em En | MEDLINE | ID: mdl-26397395
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Desenho de Fármacos / Receptor Tipo 1 de Angiotensina / Antagonistas de Receptores de Angiotensina Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Desenho de Fármacos / Receptor Tipo 1 de Angiotensina / Antagonistas de Receptores de Angiotensina Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article