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Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005.
Kim, Jong Won; Ko, Sung-Kyun; Son, Sangkeun; Shin, Kee-Sun; Ryoo, In-Ja; Hong, Young-Soo; Oh, Hyuncheol; Hwang, Bang Yeon; Hirota, Hiroshi; Takahashi, Shunji; Kim, Bo Yeon; Osada, Hiroyuki; Jang, Jae-Hyuk; Ahn, Jong Seog.
Afiliação
  • Kim JW; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; College of Pharmacy, Chungbuk National University, Chungbuk 362-763, Republic of Korea.
  • Ko SK; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Republic of Korea.
  • Son S; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Republic of Korea.
  • Shin KS; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea.
  • Ryoo IJ; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea.
  • Hong YS; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Republic of Korea.
  • Oh H; College of Pharmacy, Wonkwang University, Jeonbuk 570-749, Republic of Korea.
  • Hwang BY; College of Pharmacy, Chungbuk National University, Chungbuk 362-763, Republic of Korea.
  • Hirota H; RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Saitama 351-0198, Japan.
  • Takahashi S; RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Saitama 351-0198, Japan.
  • Kim BY; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Republic of Korea.
  • Osada H; Chemical Biology Research Group, RIKEN CSRS, Saitama 351-0198, Japan.
  • Jang JH; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Republic of Korea. Electronic address: jangjh@kribb.re.kr.
  • Ahn JS; Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Republic of Korea. Electronic address: jsahn@kribb.re.kr.
Bioorg Med Chem Lett ; 25(22): 5398-401, 2015 Nov 15.
Article em En | MEDLINE | ID: mdl-26403931
ABSTRACT
During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Dicetopiperazinas / Organismos Aquáticos Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Dicetopiperazinas / Organismos Aquáticos Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2015 Tipo de documento: Article